解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Azido-PhIP (2-azido-1-methyl-6-phenylimidazo[4,5-b]pyridine) and nitro-PhIP (2-nitro-1-methyl-6-phenylimidazo[4,5-b]pyridine) have been synthesized and characterized chemically. The mutagenic potencies of azido-PhIP (with photoactivation by near UV irradiation), of nitro-PhIP (without exogenous activation) and of the ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/12.6.1091
更新日期:1991-06-01 00:00:00
abstract::Dacarbazine (DTIC) is an antitumor agent, used for the treatment of metastatic melanoma. It is metabolized to an alkylating agent which reacts with DNA. A fast and simple method was developed in order to measure drug-induced DNA damage in lymphocytes isolated from frozen blood samples of treated patients. The level of...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/12.6.1153
更新日期:1991-06-01 00:00:00
abstract::The transforming potential of acrylonitrile epoxide (ANO) was tested in a modified NIH3T3 transfection-transformation assay. This involves a new ras construct obtained by ligating a human c-Ha-ras-1 proto-oncogene to the pSV2neo mammalian vector. The new plasmid was allowed to react with ANO or an established carcinog...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/12.5.787
更新日期:1991-05-01 00:00:00
abstract::Diethylstilbestrol (DES) is a transplacental carcinogen in humans and in rodents. As part of an attempt to examine the mechanism of transplacental carcinogenesis, the transplacental genotoxity of this stilbene estrogen has been investigated. Pregnant hamsters received single injections of 200 mg/kg DES on the 10th day...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/12.5.773
更新日期:1991-05-01 00:00:00
abstract::A monoclonal antibody specific for cyclobutane thymine dimers in DNA was used in immunofluorescence studies to detect these lesions in skin sections taken from hairless mice that had been irradiated with UV-B. The dimer-specific fluorescence in epidermal cell nuclei was quantified with fluorescence microscopy through ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/12.5.861
更新日期:1991-05-01 00:00:00
abstract::The Bowman-Birk protease inhibitor (BBI) is a legume-derived inhibitor of chymotrypsin and trypsin that has been shown to suppress cellular transformation and tumorigenesis. In the present investigation the effects of various BBI administration schedules were evaluated for suppression of 3-methylcholanthrene (3-MCA)-i...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/12.5.935
更新日期:1991-05-01 00:00:00
abstract::Crude plasma membranes were prepared from the liver of control rats or of rats submitted to an initiation by diethyl-nitrosamine and selection with 2-acetylaminofluorene and carbon tetrachloride (group IS) or of rats submitted to an initiation-selection protocol followed by a promotion with phenobarbital (group IS PB)...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/12.4.659
更新日期:1991-04-01 00:00:00
abstract::Groups of rats, either dosed with N-nitrosodiethylamine (NDEA) for 10 weeks (from the age of 7 to 17 weeks) or untreated, were fed diets containing either 2% (low fat, LF) or 30% polyunsaturated fat (high fat, HF) on an equicaloric basis from 5 weeks until rats were 43 weeks old. Biochemical parameters were measured d...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/12.4.591
更新日期:1991-04-01 00:00:00
abstract::Okadaic acid is both a potent inhibitor of protein serine/threonine phosphatases and a tumor promoter in the mouse skin model. We have previously shown that at non-toxic nanomolar concentrations okadaic acid reversibly inhibits induction (promotion) by PDGF of transformed cells by the 'complete' and 'two-stage' protoc...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/12.4.665
更新日期:1991-04-01 00:00:00
abstract::The role of bacteria in catalysing intragastric formation of N-nitrosothiazolidine-4-carboxylic acid and N-nitrosomorpholine was investigated in a rat model of omeprazole-induced achlorhydria. Omeprazole-treated rats gavaged with nitrosation-proficient bacteria were treated with nitrosamines and/or precursors and comp...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/12.3.435
更新日期:1991-03-01 00:00:00
abstract::Expression of blood group-related antigens (BGRAs) A, B, H, Le(b), Le(x) and Le(y) was examined immunohistochemically in neoplastic and hyperplastic lesions induced by N-nitrosobis(2-oxopropyl)amine in Syrian hamsters to determine a relationship between histological and biological patterns of the lesion and expression...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/12.3.441
更新日期:1991-03-01 00:00:00
abstract::The effects of alternating ad libitum feeding and 30% restriction of the dietary intake on the development of diethylnitrosamine (DEN)-induced hepatic neoplasia were investigated. Dietary restriction retarded the growth of glucose-6-phosphatase-deficient (G6Pd) preneoplastic foci and subsequently that of hepatocellula...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/12.2.311
更新日期:1991-02-01 00:00:00
abstract::A topical application of a chalcone derivative, 4,2',4'-trihydroxychalcone (isoliquiritigenin) inhibited epidermal ornithine decarboxylase (ODC) induction and ear edema formation, i.e. inflammation, caused by a topical application of 12-O-tetradecanoylphorbol-13-acetate (TPA) in CD-1 mice. In addition, isoliquiritigen...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/12.2.317
更新日期:1991-02-01 00:00:00
abstract::Male outbred Sprague-Dawley rats were fed a choline-deficient diet containing 0.10% DL-ethionine for up to 30 weeks. Liver slices from rats killed 4, 6, 10, 14, 22 and 30 weeks after starting the treatment were histochemically analyzed for the following parameters: basophilia, expression of cytokeratin 19 (which in th...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/12.2.225
更新日期:1991-02-01 00:00:00
abstract::The inability of cells in culture to grow in medium where methionine is replaced by its metabolic precursor, homocysteine, has been linked to neoplastic transformation and termed 'methionine dependence' or 'methionine auxotrophy'. The present investigation was undertaken to establish the influence of intracellular glu...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/12.2.241
更新日期:1991-02-01 00:00:00
abstract::The effects of D-limonene and citrus fruit oils, i.e. orange oil and lemon oil, on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced neoplasia of the lungs and forestomach of female A/J mice were investigated. D-Limonene and the citrus fruit oils given p.o. 1 h prior to NNK, also administered p.o., inhibite...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/12.1.115
更新日期:1991-01-01 00:00:00
abstract::We previously demonstrated that a single dose of gamma-radiation (350 rads) was able to induce thymic lymphomas in C57BL mice when followed by promoting treatment with oral cyclosporine (CsA), a non-genotoxic immunosuppressant. We have now tested the efficacy of various doses of gamma-radiation as an initiator of CsA ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/12.1.43
更新日期:1991-01-01 00:00:00
abstract::Iron exclusion has been used to identify foci of hepatocellular alteration (FHA) in rats exposed to known carcinogens. This study investigates whether basophilic FHA occurring spontaneously in aged female Fischer 344 rats also exclude iron. Female rats 514-544 days of age were given supplemental iron by injection for ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/11.12.2253
更新日期:1990-12-01 00:00:00
abstract::Using the polymerase chain reaction (PCR), a human kidney glutathione S-transferase (GST) alpha cDNA clone (GST alpha 12 K) was synthesized; it is identical to a known liver GST alpha cDNA clone except for one base change (G----A), indicating that an alpha class gene expressed in human kidney is similar to one express...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/11.12.2179
更新日期:1990-12-01 00:00:00
abstract::Repeated promotion of 7,12-dimethylbenz[alpha]anthracene-initiated cells in mouse skin with 12-O-tetradecanoylphorbol-13-acetate (TPA) induces them to grow as premalignant skin papillomas and some of these subsequently progress to carcinomas. In this study, we demonstrate that this TPA-induced progression of initiated...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/11.12.2123
更新日期:1990-12-01 00:00:00
abstract::Treatment of pregnant mice with 3-methylcholanthrene (MC) causes lung and liver tumors in the offspring, the incidences of which are greatly influenced by the Ah locus regulated induction phenotype for aryl hydrocarbon hydroxylase activity (AHH) in both the mother and fetuses. In order to examine the biochemical and m...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/11.11.1979
更新日期:1990-11-01 00:00:00
abstract::In order to study the mechanism of cancer production by aflatoxin B1 (AFB1) in extrahepatic tissues which have relatively low cytochrome P450 monooxygenase (P450) activity, we have examined prostaglandin H synthase (PHS)-mediated AFB1 activation [( 3H]AFB1-DNA binding). [3H]AFB1 was activated by both purified PHS and ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/11.11.1915
更新日期:1990-11-01 00:00:00
abstract::Using an initiation--selection--promotion protocol for induction of liver tumors in Wistar rats, the modulating action of various peroxisome proliferators on neoplasia as well as on selected biochemical parameters was studied. After treatment with diethylnitrosamine (DEN), the animals were subsequently subjected to a ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/11.11.1899
更新日期:1990-11-01 00:00:00
abstract::3-tert-Butyl-4-hydroxyanisole (3-BHA) and its metabolites, tert-butyl-1,4-benzoquinone (BQ) and 3-tert-butyl-5-methoxy-1,2-benzoquinone (BHAoQ), were tested for initiating activity in a two-stage transformation assay using BALB/3T3 cells. Cells were treated first with a test chemical and then with the tumor promoter 1...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/11.11.1985
更新日期:1990-11-01 00:00:00
abstract::Groups of male Fischer-344 rats were fed two pairs of semi-purified choline-devoid and choline-supplemented diets, one set containing 5% corn oil and 10% partially hydrogenated fat, and the other only corn oil (15%). Analyses were performed on lipids extracted from whole liver, liver nuclei and adipose tissue of the r...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/11.11.2053
更新日期:1990-11-01 00:00:00
abstract::A mouse monoclonal antibody (Mab) was prepared which showed high specificity for a potential marker of exposure to methylating carcinogens such as 3-methyladenine (3-MeAde). In a low-temperature (4 degrees C) ELISA a linear calibration curve was obtained between 3 and 50 fmol/well. In combination with an immunoaffinit...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/11.10.1747
更新日期:1990-10-01 00:00:00
abstract::The ability of sodium bisulfite to induce morphological transformation and mutagenesis of cultured Syrian hamster embryo cells was examined. Treatment of the cells at neutral pH for 15 min with 5-20 mM sodium bisulfite resulted in a dose-dependent increase in cell transformation but no induction of gene mutations meas...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/11.10.1869
更新日期:1990-10-01 00:00:00
abstract::Mutations in codon 61 of the Ha-ras proto-oncogene have been shown to occur with a high frequency in both spontaneous and carcinogen-induced liver tumours of the B6C3F1 mouse. In the present study we analysed the frequency and pattern of Ha-ras mutations in liver tumours in a different strain of mice, namely the CF1 m...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/11.10.1875
更新日期:1990-10-01 00:00:00
abstract::The mutagenicity of N-nitroso-N-benzyl-methylamine (NBzMA), N-benzyl-N-nitrosourea (BzNU) and N-methyl-N-nitrosourea (MNU) in Salmonella typhimurium strains was investigated. BzNU selectively mutated TA100 strain as compared to TA1535, whereas MNU showed an inverse strain response, an effect probably related to the fa...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/11.9.1653
更新日期:1990-09-01 00:00:00
abstract::The metabolism of zymosterol and mevalonic acid was studied in vitro using the skin homogenates of 3-methylcholanthrene (3MC), diazacholesterol-treated and untreated mice. In normal mouse skin only lathosterol was a major metabolite and the other metabolites, cholesta-5,7,24-trien-3 beta-ol, desmosterol, cholesterol a...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/11.9.1647
更新日期:1990-09-01 00:00:00
abstract::Procarbazine hydrochloride (PCZ), a chemotherapeutic agent used extensively to treat Hodgkins disease and other tumors, induces leukemia, lymphoma, mammary gland and other solid tumors in rodents and non-human primates and is strongly implicated as a leukemogen in humans. Lipotrope (choline and methionine) deficiency ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/11.9.1491
更新日期:1990-09-01 00:00:00
abstract::Two solid-phase extraction methods were developed for the determination of mutagenic heterocyclic aromatic amines in heated meat products. The copper phthalocyanine (CPC) tandem extraction was performed on coupled cartridges of diatomaceous earth and CPC-derivatized Sephasorb HP, followed by further clean-up on Sephas...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/11.9.1597
更新日期:1990-09-01 00:00:00
abstract::Absorption, metabolism and DNA binding of 2-nitrofluorene (NF) was studied in isolated, perfused and ventilated rat lungs and in lung microsomal incubations. Comparisons were made between control animals and animals treated with beta-naphthoflavone (BNF), a 2,3,7,8-tetrachlorodibenzo(rho)dioxin (TCDD) receptor ligand ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/11.8.1249
更新日期:1990-08-01 00:00:00
abstract::Continuous dietary administration of the hepatocarcinogen 2-acetylaminofluorene (AAF) to rats produces a gradual increase in hepatic DNA adducts until a plateau is reached after approximately 2 weeks. The rate of DNA adduct formation remains constant through 1 month of AAF feeding, while adduct removal profiles are bi...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/11.8.1343
更新日期:1990-08-01 00:00:00
abstract::Previous reports showed that skin fibroblasts or peripheral blood lymphocytes from individuals with hereditary cancer or with a genetic disorder predisposing to cancer show an abnormally high frequency of chromatid damage after X-irradiation in G2 phase. The reproducibility of this response suggested that it could pro...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/11.8.1425
更新日期:1990-08-01 00:00:00
abstract::There is no unique mechanism to explain the activity in animals of 'non-genotoxic' carcinogens. In this they differ from 'genotoxic' carcinogens that are DNA reactive. In the present study it is reported that non-mutagenic carcinogens, as a group, have significantly higher computed octanol/water partition coefficients...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/11.7.1111
更新日期:1990-07-01 00:00:00
abstract::Treatment of murine Swiss 3T3 fibroblasts and XB/2 keratinocytes with UV-B light (302 nm) resulted in a dose-dependent inhibition of [125I]epidermal growth factor (EGF) binding. The light dose required to achieve 50% inhibition of binding in both cell types was 80-85 J/m2. Decreased [125I]platelet-derived growth facto...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/11.7.1223
更新日期:1990-07-01 00:00:00
abstract::To study the mechanisms of mutagenesis by the carcinogen N-acetyl-2-aminofluorene (AAF), we determined by DNA sequencing the spectrum of mutations in the Escherichia coli lacI gene induced by the ultimate metabolite N-acetoxy-N-acetyl-2-aminofluorene, using an E. coli derivative with increased permeability to this com...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/11.7.1087
更新日期:1990-07-01 00:00:00
abstract::Bioassays and DNA-binding studies of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and its analogs with deuterium substitution at the positions alpha to the nitrosamino group ([4,4-D2]NNK and [CD3]NNK) were carried out in A/J mice in order to assess the potential importance of DNA methylation or pyridyloxobutyl...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/11.6.1017
更新日期:1990-06-01 00:00:00
abstract::Transgenic mice containing one copy of hepatitis B virus (HBV) genome without the core gene and expressing hepatitis B surface antigen (HBsAg) were crossed with C3H/He mice. The F1 hybrids (approximately 50% HBV positive and approximately 50% HBV negative) were treated with a single dose of diethylnitrosamine (NDEA) o...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/11.6.953
更新日期:1990-06-01 00:00:00